Dual-Energy CT Deep Learning Radiomics to Predict Macrotrabecular-Massive Hepatocellular Carcinoma.

Journal: Radiology
Published Date: Aug 1, 2023

Abstract

Background It is unknown whether the additional information provided by multiparametric dual-energy CT (DECT) could improve the noninvasive diagnosis of the aggressive macrotrabecular-massive (MTM) subtype of hepatocellular carcinoma (HCC). Purpose To evaluate the diagnostic performance of dual-phase contrast-enhanced multiparametric DECT for predicting MTM HCC. Materials and Methods Patients with histopathologic examination-confirmed HCC who underwent contrast-enhanced DECT between June 2019 and June 2022 were retrospectively recruited from three independent centers (center 1, training and internal test data set; centers 2 and 3, external test data set). Radiologic features were visually analyzed and combined with clinical information to establish a clinical-radiologic model. Deep learning (DL) radiomics models were based on DL features and handcrafted features extracted from virtual monoenergetic images and material composition images on dual phase using binary least absolute shrinkage and selection operators. A DL radiomics nomogram was developed using multivariable logistic regression analysis. Model performance was evaluated with the area under the receiver operating characteristic curve (AUC), and the log-rank test was used to analyze recurrence-free survival. Results A total of 262 patients were included (mean age, 54 years ± 12 [SD]; 225 men [86%]; training data set, = 146 [56%]; internal test data set, = 35 [13%]; external test data set, = 81 [31%]). The DL radiomics nomogram better predicted MTM than the clinical-radiologic model (AUC = 0.91 vs 0.77, respectively, for the training set [ < .001], 0.87 vs 0.72 for the internal test data set [ = .04], and 0.89 vs 0.79 for the external test data set [ = .02]), with similar sensitivity (80% vs 87%, respectively; = .63) and higher specificity (90% vs 63%; < .001) in the external test data set. The predicted positive MTM groups based on the DL radiomics nomogram had shorter recurrence-free survival than predicted negative MTM groups in all three data sets (training data set, = .04; internal test data set, = .01; and external test data set, = .03). Conclusion A DL radiomics nomogram derived from multiparametric DECT accurately predicted the MTM subtype in patients with HCC. © RSNA, 2023 See also the editorial by Chu and Fishman in this issue.

Authors

  • Mengsi Li
    From the Departments of Radiology (M. Li, C.L., A.L., L.Z., Jinhui Zhou, D.Z., H.C., Y.X., J.W.) and Pathology (Jing Zhou), The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Rd, Guangzhou, Guangdong, 510630, People's Republic of China; Medical AI Laboratory, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, People's Republic of China (Y.F., B.H.); Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China (H.Y.); Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China (M. Luo); and Department of Clinical Science, Philips Healthcare China, Shanghai, People's Republic of China (X.Y., W.D., Z.Z.).
  • Yaheng Fan
    From the Departments of Radiology (M. Li, C.L., A.L., L.Z., Jinhui Zhou, D.Z., H.C., Y.X., J.W.) and Pathology (Jing Zhou), The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Rd, Guangzhou, Guangdong, 510630, People's Republic of China; Medical AI Laboratory, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, People's Republic of China (Y.F., B.H.); Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China (H.Y.); Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China (M. Luo); and Department of Clinical Science, Philips Healthcare China, Shanghai, People's Republic of China (X.Y., W.D., Z.Z.).
  • Huayu You
    From the Departments of Radiology (M. Li, C.L., A.L., L.Z., Jinhui Zhou, D.Z., H.C., Y.X., J.W.) and Pathology (Jing Zhou), The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Rd, Guangzhou, Guangdong, 510630, People's Republic of China; Medical AI Laboratory, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, People's Republic of China (Y.F., B.H.); Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China (H.Y.); Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China (M. Luo); and Department of Clinical Science, Philips Healthcare China, Shanghai, People's Republic of China (X.Y., W.D., Z.Z.).
  • Chao Li
    McGill University Health Centre, McGill Adult Unit for Congenital Heart Disease Excellence, Montreal, Québec, Canada.
  • Ma Luo
    From the Departments of Radiology (M. Li, C.L., A.L., L.Z., Jinhui Zhou, D.Z., H.C., Y.X., J.W.) and Pathology (Jing Zhou), The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Rd, Guangzhou, Guangdong, 510630, People's Republic of China; Medical AI Laboratory, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, People's Republic of China (Y.F., B.H.); Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China (H.Y.); Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China (M. Luo); and Department of Clinical Science, Philips Healthcare China, Shanghai, People's Republic of China (X.Y., W.D., Z.Z.).
  • Jing Zhou
  • Anqi Li
    Department of Hygiene Detection Center, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, Guangdong, China.
  • Lina Zhang
    Intensive Care Unit, XiangYa Hospital, Central South University, Changsha, China.
  • Xiao Yu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Weiwei Deng
    Key Laboratory of Dependable Services Computing in Cyber-Physical Society (Chongqing) Ministry of Education, College of Computer Science, Chongqing University, Chongqing, 400044, China.
  • Jinhui Zhou
    National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Dingyue Zhang
    Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
  • Zhongping Zhang
    Philips Healthcare, Guangzhou, China.
  • Haimei Chen
    From the Departments of Radiology (M. Li, C.L., A.L., L.Z., Jinhui Zhou, D.Z., H.C., Y.X., J.W.) and Pathology (Jing Zhou), The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Rd, Guangzhou, Guangdong, 510630, People's Republic of China; Medical AI Laboratory, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, People's Republic of China (Y.F., B.H.); Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China (H.Y.); Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China (M. Luo); and Department of Clinical Science, Philips Healthcare China, Shanghai, People's Republic of China (X.Y., W.D., Z.Z.).
  • Yuanqiang Xiao
    From the Departments of Radiology (M. Li, C.L., A.L., L.Z., Jinhui Zhou, D.Z., H.C., Y.X., J.W.) and Pathology (Jing Zhou), The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Rd, Guangzhou, Guangdong, 510630, People's Republic of China; Medical AI Laboratory, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, People's Republic of China (Y.F., B.H.); Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China (H.Y.); Department of Radiology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China (M. Luo); and Department of Clinical Science, Philips Healthcare China, Shanghai, People's Republic of China (X.Y., W.D., Z.Z.).
  • Bingsheng Huang
    School of Biomedical Engineering, Shenzhen University Health Sciences Center, Shenzhen, Guangdong 518060, P.R.China.
  • Jin Wang
    Cells Vision (Guangzhou) Medical Technology Inc., Guangzhou, China. Electronic address: wangjin@cellsvision.com.

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