Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI.

Journal: AJNR. American journal of neuroradiology
PMID: 37562826

Abstract

BACKGROUND AND PURPOSE: The nucleus basalis of Meynert is a key subcortical structure that is important in arousal and cognition and has been explored as a deep brain stimulation target but is difficult to study due to its small size, variability among patients, and lack of contrast on 3T MR imaging. Thus, our goal was to establish and evaluate a deep learning network for automatic, accurate, and patient-specific segmentations with 3T MR imaging.

Authors

  • D J Doss
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee derekjdoss@gmail.com.
  • G W Johnson
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • S Narasimhan
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • J S Shless
    Institute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • J W Jiang
    Institute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • H F J González
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • D L Paulo
    Department of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.), Vanderbilt University Medical Center, Nashville, Tennessee.
  • A Lucas
    Department of Bioengineering (A.L.), University of Pennsylvania, Philadelphia, Pennsylvania.
  • K A Davis
    Department of Neuroscience (K.A.D.), University of Pennsylvania, Philadelphia, Pennsylvania.
  • C Chang
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • V L Morgan
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • C Constantinidis
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • B M Dawant
    Institute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Vanderbilt University, Nashville, Tennessee.
  • D J Englot
    From the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.), Vanderbilt University, Nashville, Tennessee.

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