Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma.

Journal: BMC medicine
PMID: 37553571

Abstract

BACKGROUND: Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor, and its diagnosis is still a challenge. This study aimed to identify a novel bile marker for CCA diagnosis based on proteomics and establish a diagnostic model with deep learning.

Authors

  • Long Gao
    College of Computer, National University of Defense Technology, Changsha 410073, China; Department of Radiology, School of Medicine, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, PA 15260, USA.
  • Yanyan Lin
    School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, PR China.
  • Ping Yue
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Shuyan Li
  • Yong Zhang
    Outpatient Department of Hepatitis, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Ningning Mi
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Mingzhen Bai
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Wenkang Fu
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Zhili Xia
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Ningzu Jiang
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Jie Cao
    College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Man Yang
    Clinical Research Center, Big Data Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China.
  • Yanni Ma
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Fanxiang Zhang
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China.
  • Chao Zhang
    School of Information Engineering, Suqian University, Suqian, Jiangsu, China.
  • Joseph W Leung
    Division of Gastroenterology, UC Davis Medical Center and Sacramento VA Medical Center, Sacramento, CA, 95817, USA.
  • Shun He
    School of Mathematical Sciences, Peking University, Beijing, China.
  • Jinqiu Yuan
    Big Data Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, P.R. China.
  • Wenbo Meng
    The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730030, Gansu, China. mengwb@lzu.edu.cn.
  • Xun Li
    Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, China.

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