Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study.

Journal: Pediatric rheumatology online journal
PMID:

Abstract

BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in patients with JIA.

Authors

  • Nicolino Ruperto
    Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy. nicolaruperto@gaslini.org.
  • Hermine I Brunner
    Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA.
  • Zbigniew Zuber
    St Louis Children's Hospital ODS Rheumatology and Neurology, Krakow, Poland.
  • Nikolay Tzaribachev
    Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany.
  • Daniel J Kingsbury
    Randall Children's Hospital, Portland, OR, USA.
  • Ivan Foeldvari
    Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany.
  • Gerd Horneff
    Centre of General Pediatrics and Neonatology, Asklepios Klinik, Sankt Augustin, Germany.
  • Elzbieta Smolewska
    Department of Pediatric Rheumatology, Medical University of Lodz, Lodz, Poland.
  • Richard K Vehe
    University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
  • Anasuya Hazra
    Pfizer Inc, Collegeville, PA, USA.
  • Rong Wang
    College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shanxi, China. Electronic address: wangrong91@nwsuaf.edu.cn.
  • Charles A Mebus
    Pfizer Inc, Groton, CT, USA.
  • Christine Alvey
    Pfizer Inc, Groton, CT, USA.
  • Manisha Lamba
    Pfizer Inc, Groton, CT, USA.
  • Sriram Krishnaswami
    Pfizer Inc, Groton, CT, USA.
  • Thomas C Stock
    Pfizer Inc, Collegeville, PA, USA.
  • Min Wang
    National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Wenzhou University, Wenzhou 325035, China.
  • Ricardo Suehiro
    Pfizer Inc, Collegeville, PA, USA.
  • Alberto Martini
    University of Genoa, Italy.
  • Daniel J Lovell
    Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, USA.