Intestinal motility, including peristalsis and segmentation, drives complex fluid movements critical for the oral delivery of biologics and other macromolecules. Despite advances, oral delivery remains commercially limited by low bioavailability, oft...
International journal of pharmaceutics
Dec 8, 2025
Driven by the Food and Drug Administration's Quality-by-Design initiative and the advancements of Industry 4.0, the pharmaceutical industry is transitioning from traditional batch manufacturing to advanced manufacturing. This transition requires resh...
International journal of pharmaceutics
Nov 24, 2025
Over the past two decades, a diverse array of ultrasonic and acoustic elastic-wave techniques has been developed to non-destructively assess macro- and micro-scale properties of compressed Oral Solid Dosage (OSD) forms. These methods are increasingly...
Existing oral drug delivery modalities often fall short in medical emergencies due to the absence of readily deployable, internalized drug storage and delivery mechanisms that combine long-term standby with rapid activation. To address this challenge...
We conducted a multicenter retrospective analysis of 408 patients diagnosed with onychomycosis who attended three tertiary care Spanish hospitals. The study was conducted to assess the clinical characteristics and outcomes of onychomycosis patients u...
Toxicological evaluation of industrial chemicals with a broad range of chemical structures, for example, bioactive food components, toxic food-derived compounds, and drugs, usually involves the estimation of human clearance by allometric extrapolatio...
Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited. In this study, we use several artificial intelligence techniques and patient-based mult...
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Apr 24, 2025
BACKGROUND: Oral Immunotherapy (OIT) has exhibited great potential in the treatment of food allergy. However, there is no global consensus on best practices of OIT. Parents of allergic children often struggle with concerns regarding OIT methodology, ...
British journal of clinical pharmacology
Apr 7, 2025
AIMS: The incidence of osteoporosis is projected to exceed 70 million people over the age of 65 years by 2030. Osteoanabolic agents, such as teriparatide and abaloparatide, are not only effective in reducing fracture incidence but also improve skelet...
ETHNOPHARMACOLOGICAL RELEVANCE: The species Siparuna guianensis Aublet (family Siparunaceae) is traditionally used by indigenous peoples and riverine communities in Central and South America to treat migraines, flu, respiratory diseases, fever, pain,...
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