EMDL_m6Am: identifying N6,2'-O-dimethyladenosine sites based on stacking ensemble deep learning.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: N6, 2'-O-dimethyladenosine (mAm) is an abundant RNA methylation modification on vertebrate mRNAs and is present in the transcription initiation region of mRNAs. It has recently been experimentally shown to be associated with several human disorders, including obesity genes, and stomach cancer, among others. As a result, N6,2'-O-dimethyladenosine (mAm) site will play a crucial part in the regulation of RNA if it can be correctly identified.

Authors

  • Jianhua Jia
    School of Information Engineering, Jingdezhen Ceramic University, Jingdezhen, 333403, China. jjh163yx@163.com.
  • Zhangying Wei
    School of Information Engineering, Jingdezhen Ceramic University, Jingdezhen, 333403, China. weizy5003@163.com.
  • Mingwei Sun
    Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun 130012, China.