Clinical Validation of Artificial Intelligence-Augmented Pathology Diagnosis Demonstrates Significant Gains in Diagnostic Accuracy in Prostate Cancer Detection.

Journal: Archives of pathology & laboratory medicine
PMID: 36538386

Abstract

CONTEXT.—: Prostate cancer diagnosis rests on accurate assessment of tissue by a pathologist. The application of artificial intelligence (AI) to digitized whole slide images (WSIs) can aid pathologists in cancer diagnosis, but robust, diverse evidence in a simulated clinical setting is lacking.

Authors

  • Patricia Raciti
    Paige.AI, 11 East Loop Road, FL5, New York, NY, 10044, USA. patricia.raciti@paige.ai.
  • Jillian Sue
    Paige.AI, 11 East Loop Road, FL5, New York, NY, 10044, USA.
  • Juan A Retamero
    From Paige (Raciti, Sue, Retamero, Ceballos, Godrich, Kunz, Casson, Thiagarajan, Ebrahimzadeh, Viret, Lee, Schüffler, Gulturk, Kanan, Rothrock, Klimstra, Fuchs), New York, New York.
  • Rodrigo Ceballos
    Paige.AI, 11 East Loop Road, FL5, New York, NY, 10044, USA.
  • Ran Godrich
    Paige.AI, 11 East Loop Road, FL5, New York, NY, 10044, USA.
  • Jeremy D Kunz
    Paige.AI, 11 East Loop Road, FL5, New York, NY, 10044, USA.
  • Adam Casson
    Paige, New York, NY, USA.
  • Dilip Thiagarajan
    From Paige (Raciti, Sue, Retamero, Ceballos, Godrich, Kunz, Casson, Thiagarajan, Ebrahimzadeh, Viret, Lee, Schüffler, Gulturk, Kanan, Rothrock, Klimstra, Fuchs), New York, New York.
  • Zahra Ebrahimzadeh
    From Paige (Raciti, Sue, Retamero, Ceballos, Godrich, Kunz, Casson, Thiagarajan, Ebrahimzadeh, Viret, Lee, Schüffler, Gulturk, Kanan, Rothrock, Klimstra, Fuchs), New York, New York.
  • Julian Viret
    Paige, New York, NY, USA.
  • Donghun Lee
    School of Mechanical Engineering, Soongsil University, Seoul, Korea.
  • Peter J Schüffler
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
  • George DeMuth
    Stat One, Wilmington, NC, USA.
  • Emre Gulturk
    From Paige (Raciti, Sue, Retamero, Ceballos, Godrich, Kunz, Casson, Thiagarajan, Ebrahimzadeh, Viret, Lee, Schüffler, Gulturk, Kanan, Rothrock, Klimstra, Fuchs), New York, New York.
  • Christopher Kanan
    Chester F. Carlson Center for Imaging Science, Rochester Institute of Technology, NY, USA.
  • Brandon Rothrock
    Jet Propulsion Laboratory, Caltech, Los Angeles, CA 91109, USA.
  • Jorge Reis-Filho
    The Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York (Reis-Filho, Reuter).
  • David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Victor Reuter
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • Thomas J Fuchs
    Weill Cornell Medicine, New York, USA; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address: gac2010@med.cornell.edu.

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