A systematic review of the development and application of home cage monitoring in laboratory mice and rats.

Journal: BMC biology
Published Date:

Abstract

BACKGROUND: Traditionally, in biomedical animal research, laboratory rodents are individually examined in test apparatuses outside of their home cages at selected time points. However, the outcome of such tests can be influenced by various factors and valuable information may be missed when the animals are only monitored for short periods. These issues can be overcome by longitudinally monitoring mice and rats in their home cages. To shed light on the development of home cage monitoring (HCM) and the current state-of-the-art, a systematic review was carried out on 521 publications retrieved through PubMed and Web of Science.

Authors

  • Pia Kahnau
    German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany.
  • Paul Mieske
    German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany.
  • Jenny Wilzopolski
    German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany.
  • Otto Kalliokoski
    Department of Experimental Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Silvia Mandillo
    Institute of Biochemistry and Cell Biology, National Research Council CNR, Rome, Italy.
  • Sabine M Hölter
    Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany.
  • Vootele Voikar
    Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
  • Adriana Amfim
    Faculty of Veterinary Medicine, Spiru Haret University, Bucharest, Romania.
  • Sylvia Badurek
    Preclinical Phenotyping Facility, Vienna Biocenter Core Facilities (VBCF), member of the Vienna Biocenter (VBC), Vienna, Austria.
  • Aleksandra Bartelik
    International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
  • Angela Caruso
    Istituto Superiore Di Sanità, Research Coordination and Support Service, Rome, Italy.
  • Maša Čater
    Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
  • Elodie Ey
    Human Genetics and Cognitive Functions, Institut Pasteur, UMR 3571 CNRS, University Paris-Diderot, Paris, France. elodie.ey@pasteur.fr.
  • Elisabetta Golini
    Institute of Biochemistry and Cell Biology, National Research Council CNR, Rome, Italy.
  • Anne Jaap
    Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
  • Dragan Hrncic
    Institute of Medical Physiology "Richard Burian", Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Anna Kiryk
    Laboratory of Preclinical Testing of Higher Standard, Neurobiology Center, Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw, Poland.
  • Benjamin Lang
    Baylor College of Medicine.
  • Natasa Loncarevic-Vasiljkovic
    iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade Nova de Lisboa, Lisbon, Portugal.
  • Hamid Meziane
    Université de Strasbourg, CNRS, INSERM, Institut Clinique de La Souris (ICS), CELPHEDIA, PHENOMIN, 1 Rue Laurent Fries, Illkirch, 67404, France.
  • Aurelija Radzevičienė
    Lithuanian University of Health Sciences, Medical Academy, Institute of Physiology and Pharmacology, Kaunas, Lithuania.
  • Marion Rivalan
    Research Institute for Experimental Medicine (FEM) and NeuroCure Cluster of Excellence, Animal Behaviour Phenotyping Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Maria Luisa Scattoni
    Research Coordination and Support Service, Istituto Superiore di Sanità, Rome, Italy.
  • Nicolas Torquet
    Sorbonne Université, CNRS UMR 8246, INSERM, Neurosciences Paris Seine - Institut de Biologie Paris-Seine, Paris, France.
  • Julijana Trifkovic
    Department of Veterinary Medicine, Faculty of Agriculture, University of East Sarajevo, East Sarajevo, Bosnia and Herzegovina.
  • Brun Ulfhake
    Div. Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Christa Thöne-Reineke
    Institute of Animal Welfare, Animal Behavior, and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
  • Kai Diederich
    German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany.
  • Lars Lewejohann
    Institute of Animal Welfare, Animal Behavior, and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
  • Katharina Hohlbaum
    Institute of Animal Welfare, Animal Behavior, and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.