Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
PMID: 29267138

Abstract

PURPOSE: Lifitegrast is approved in the United States for the treatment of dry eye disease (DED). We assessed lifitegrast's ocular distribution/pharmacokinetic profile in rabbits, and C-lifitegrast mass balance/excretion in dogs.

Authors

  • Jou-Ku Chung
    1 Shire, Lexington, Massachusetts.
  • Elizabeth Spencer
    2 Covance Laboratories, Inc. , Madison, Wisconsin.
  • Matthew Hunt
    2 Covance Laboratories, Inc. , Madison, Wisconsin.
  • Thomas McCauley
    1 Shire, Lexington, Massachusetts.
  • Devin Welty
    1 Shire, Lexington, Massachusetts.

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