5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.

Journal: Journal of surgical oncology
PMID: 29266509

Abstract

BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-fluorouracil (5-FU) combined with cisplatin (CDDP) and mitomycin C (MMC) in vitro for clinical use of HIPEC.

Authors

  • Satoshi Murata
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Hiroshi Yamamoto
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Tomoharu Shimizu
  • Hiroyuki Naitoh
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Tsuyoshi Yamaguchi
  • Sachiko Kaida
  • Katsushi Takebayashi
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Toru Miyake
  • Tohru Tani
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Masaji Tani

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