Metabolic profiling during COVID-19 infection in humans: Identification of potential biomarkers for occurrence, severity and outcomes using machine learning.

Journal: PloS one
PMID: 38814977

Abstract

BACKGROUND: After its emergence in China, the coronavirus SARS-CoV-2 has swept the world, leading to global health crises with millions of deaths. COVID-19 clinical manifestations differ in severity, ranging from mild symptoms to severe disease. Although perturbation of metabolism has been reported as a part of the host response to COVID-19 infection, scarce data exist that describe stage-specific changes in host metabolites during the infection and how this could stratify patients based on severity.

Authors

  • Gamalat A Elgedawy
    Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Mohamed Samir
    Faculty of Veterinary Medicine, Department of Zoonoses, Zagazig University, Zagazig, Egypt.
  • Naglaa S Elabd
    Faculty of Medicine, Department of Tropical Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Hala H Elsaid
    Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Mohamed Enar
    Al Mahala Elkobra Fever Hospital, Al Mahala Elkobra, Egypt.
  • Radwa H Salem
    Department of Clinical Microbiology and Immunology, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Belal A Montaser
    Faculty of Medicine, Department of Clinical Pathology, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Hind S AboShabaan
    Ph.D. of Biochemistry, National Liver Institute Hospital, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Randa M Seddik
    Faculty of Medicine, Department of Tropical Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Shimaa M El-Askaeri
    Department of Clinical Microbiology and Immunology, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Marwa M Omar
    Faculty of Medicine, Department of Clinical Pathology, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
  • Marwa L Helal
    Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

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