Deep Trans-Omic Network Fusion for Molecular Mechanism of Alzheimer's Disease.

Journal: Journal of Alzheimer's disease : JAD
Published Date: Jan 1, 2024

Abstract

BACKGROUND: There are various molecular hypotheses regarding Alzheimer's disease (AD) like amyloid deposition, tau propagation, neuroinflammation, and synaptic dysfunction. However, detailed molecular mechanism underlying AD remains elusive. In addition, genetic contribution of these molecular hypothesis is not yet established despite the high heritability of AD.

Authors

  • Linhui Xie
    Department of Electrical and Computer Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.
  • Yash Raj
    Department of BioHealth Informatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.
  • Pradeep Varathan
    Department of BioHealth Informatics, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.
  • Bing He
    School of Business, Jiangsu Ocean University, Haizhou District, Lianyungang, Jiangsu, China.
  • Meichen Yu
    Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, United States.
  • Kwangsik Nho
    Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Paul Salama
    Department of Electrical and Computer Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202, USA. psalama@iu.edu.
  • Andrew J Saykin
    Indiana University, Indianapolis, IN 46202, USA.
  • Jingwen Yan
    Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

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