An ensemble deep learning diagnostic system for determining Clinical Activity Scores in thyroid-associated ophthalmopathy: integrating multi-view multimodal images from anterior segment slit-lamp photographs and facial images.

Journal: Frontiers in endocrinology
PMID: 38628586

Abstract

BACKGROUND: Thyroid-associated ophthalmopathy (TAO) is the most prevalent autoimmune orbital condition, significantly impacting patients' appearance and quality of life. Early and accurate identification of active TAO along with timely treatment can enhance prognosis and reduce the occurrence of severe cases. Although the Clinical Activity Score (CAS) serves as an effective assessment system for TAO, it is susceptible to assessor experience bias. This study aimed to develop an ensemble deep learning system that combines anterior segment slit-lamp photographs of patients with facial images to simulate expert assessment of TAO.

Authors

  • Chunfang Yan
    Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
  • Zhaoxia Zhang
    Department of Laboratory Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumuqi, 830000, China.
  • Guanghua Zhang
    Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
  • Han Liu
    Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors, State Key Laboratory of Radio Frequency Heterogeneous Integration, Shenzhen University, Shenzhen 518060, China.
  • Ruiqi Zhang
    Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China.
  • Guiqin Liu
    Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
  • Jing Rao
    Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, China.
  • Weihua Yang
    Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong Province, China.
  • Bin Sun
    Department of Urology, General Hospital of the Air Force, PLA, No. 30 Fucheng Road Haidian District, Beijing, 100142 China.

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