AIMC Topic: Graves Ophthalmopathy
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Machine learning unveils hypoxia-immune gene hub for clinical stratification of thyroid-associated ophthalmopathy.
Scientific reports
Jul 1, 2025
Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder affecting the orbit, potentially resulting in blindness. This study focused on the role of hypoxia in its pathogenesis through integrative bioinformatics and experimental validation. F...
Comparative analysis of deep learning architectures for thyroid eye disease detection using facial photographs.
BMC ophthalmology
Apr 1, 2025
PURPOSE: To compare two artificial intelligence (AI) models, residual neural networks ResNet-50 and ResNet-101, for screening thyroid eye disease (TED) using frontal face photographs, and to test these models under clinical conditions.
TEDML: a new machine learning (ML) approach for predicting thyroid eye disease and identifying key biomarkers.
The Journal of endocrinology
Mar 14, 2025
Thyroid eye disease (TED) features immune infiltration and metabolic dysregulation. Understanding these processes and identifying potential biomarkers are crucial for improving diagnosis and treatment. To this end, immune cell infiltration was analyz...
CT-Based Machine Learning Radiomics Analysis to Diagnose Dysthyroid Optic Neuropathy.
Seminars in ophthalmology
Feb 19, 2025
PURPOSE: To develop CT-based machine learning radiomics models used for the diagnosis of dysthyroid optic neuropathy (DON).
Investigating factors influencing quality of life in thyroid eye disease: insight from machine learning approaches.
European thyroid journal
Jan 9, 2025
AIMS: Thyroid eye disease (TED) is an autoimmune orbital disorder that diminishes the quality of life (QOL) in affected individuals. Graves' ophthalmopathy (GO)-QOL questionnaire effectively assesses TED's effect on patients. This study aims to inves...
Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.
Frontiers in immunology
Dec 13, 2024
BACKGROUND: Thyroid-associated orbitopathy (TAO) is an autoimmune inflammatory disorder of the orbital adipose tissue, primarily causing oxidative stress injury and tissue remodeling in the orbital connective tissue. Ferroptosis is a form of programm...
Potential impact of organophosphate esters on thyroid eye disease based on machine learning and molecular docking.
The Science of the total environment
Dec 3, 2024
Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers in daily commodities and building materials. Some OPEs, acting as agonists of the thyroid-stimulating hormone receptor (TSHR), may contribute to the development of thy...
Neural network-based automated proptosis measurement using computed tomography images for patients with thyroid-associated orbitopathy.
Scientific reports
Nov 8, 2024
The purpose of this study was to evaluate the clinical feasibility and reliability of a neural network (NN)-based automated proptosis measurement system using computed tomography (CT) images. An automated proptosis measurement system was developed us...
CT-based artificial intelligence prediction model for ocular motility score of thyroid eye disease.
Endocrine
Jul 24, 2024
PURPOSE: Thyroid eye disease (TED) is the most common orbital disease in adults. Ocular motility restriction is the primary complaint of patients, while its evaluation is quite difficult. The present study aimed to introduce an artificial intelligenc...
Alterations in dynamic regional homogeneity within default mode network in patients with thyroid-associated ophthalmopathy.
Neuroreport
Jun 1, 2024
Thyroid-associated ophthalmopathy (TAO) is a significant autoimmune eye disease known for causing exophthalmos and substantial optic nerve damage. Prior investigations have solely focused on static functional MRI (fMRI) scans of the brain in TAO pati...
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