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Graves Ophthalmopathy

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Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.

Frontiers in immunology
BACKGROUND: Thyroid-associated orbitopathy (TAO) is an autoimmune inflammatory disorder of the orbital adipose tissue, primarily causing oxidative stress injury and tissue remodeling in the orbital connective tissue. Ferroptosis is a form of programm...

Advances in artificial intelligence in thyroid-associated ophthalmopathy.

Frontiers in endocrinology
Thyroid-associated ophthalmopathy (TAO), also referred to as Graves' ophthalmopathy, is a medical condition wherein ocular complications arise due to autoimmune thyroid illness. The diagnosis of TAO, reliant on imaging, typical ocular symptoms, and a...

Deep-Learning Based Automated Segmentation and Quantitative Volumetric Analysis of Orbital Muscle and Fat for Diagnosis of Thyroid Eye Disease.

Investigative ophthalmology & visual science
PURPOSE: Thyroid eye disease (TED) is characterized by proliferation of orbital tissues and complicated by compressive optic neuropathy (CON). This study aims to utilize a deep-learning (DL)-based automated segmentation model to segment orbital muscl...

Alterations in dynamic regional homogeneity within default mode network in patients with thyroid-associated ophthalmopathy.

Neuroreport
Thyroid-associated ophthalmopathy (TAO) is a significant autoimmune eye disease known for causing exophthalmos and substantial optic nerve damage. Prior investigations have solely focused on static functional MRI (fMRI) scans of the brain in TAO pati...

CT-based artificial intelligence prediction model for ocular motility score of thyroid eye disease.

Endocrine
PURPOSE: Thyroid eye disease (TED) is the most common orbital disease in adults. Ocular motility restriction is the primary complaint of patients, while its evaluation is quite difficult. The present study aimed to introduce an artificial intelligenc...

Neural network-based automated proptosis measurement using computed tomography images for patients with thyroid-associated orbitopathy.

Scientific reports
The purpose of this study was to evaluate the clinical feasibility and reliability of a neural network (NN)-based automated proptosis measurement system using computed tomography (CT) images. An automated proptosis measurement system was developed us...

Potential impact of organophosphate esters on thyroid eye disease based on machine learning and molecular docking.

The Science of the total environment
Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers in daily commodities and building materials. Some OPEs, acting as agonists of the thyroid-stimulating hormone receptor (TSHR), may contribute to the development of thy...

Investigating factors influencing quality of life in thyroid eye disease: insight from machine learning approaches.

European thyroid journal
AIMS: Thyroid eye disease (TED) is an autoimmune orbital disorder that diminishes the quality of life (QOL) in affected individuals. Graves' ophthalmopathy (GO)-QOL questionnaire effectively assesses TED's effect on patients. This study aims to inves...

TEDML: a new machine learning (ML) approach for predicting thyroid eye disease and identifying key biomarkers.

The Journal of endocrinology
Thyroid eye disease (TED) features immune infiltration and metabolic dysregulation. Understanding these processes and identifying potential biomarkers are crucial for improving diagnosis and treatment. To this end, immune cell infiltration was analyz...

Comparative analysis of deep learning architectures for thyroid eye disease detection using facial photographs.

BMC ophthalmology
PURPOSE: To compare two artificial intelligence (AI) models, residual neural networks ResNet-50 and ResNet-101, for screening thyroid eye disease (TED) using frontal face photographs, and to test these models under clinical conditions.