Large-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study.

Journal: Journal of child psychology and psychiatry, and allied disciplines
PMID: 38287782

Abstract

BACKGROUND: Understanding the prenatal origins of children's psychopathology is a fundamental goal in developmental and clinical science. Recent research suggests that inflammation during pregnancy can trigger a cascade of fetal programming changes that contribute to vulnerability for the emergence of psychopathology. Most studies, however, have focused on a handful of proinflammatory cytokines and have not explored a range of prenatal biological pathways that may be involved in increasing postnatal risk for emotional and behavioral difficulties.

Authors

  • Jessica L Buthmann
    Department of Psychology, Stanford University, Stanford, CA, USA.
  • Jonas G Miller
    Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
  • Nima Aghaeepour
    Departments of Anesthesiology, Pain, and Peri-operative Medicine and Biomedical Data Sciences, Stanford University, Stanford, CA, USA.
  • Lucy S King
    Department of Psychology, Stanford University, Stanford, CA, USA.
  • David K Stevenson
    March of Dimes Prematurity Center, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
  • Gary M Shaw
    March of Dimes Prematurity Center, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
  • Ronald J Wong
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Ian H Gotlib
    Department of Psychology, Stanford University, Stanford, CA, USA.

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