Lymph node metastases and recurrence in pT1 colorectal cancer: Prediction with the International Budding Consortium Score-A retrospective, multi-centric study.

Journal: United European gastroenterology journal
Published Date:

Abstract

BACKGROUND: The International Collaboration on Cancer Reporting proposes histological tumour type, lymphovascular invasion, tumour grade, perineural invasion, extent, and dimensions of invasion as risk factors for lymph node metastases and tumour progression in completely endoscopically resected pT1 colorectal cancer (CRC).

Authors

  • Heather Dawson
    Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.
  • John-Melle Bokhorst
    Diagnostic Image Analysis Group and the Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Linda Studer
    Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.
  • Michael Vieth
    Klinikum of Pathology, Bayreuth University, Bayreuth, Germany.
  • Ayse Selcen Oguz Erdogan
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Sonay Kus Öztürk
    Department of Pathology, Radboudumc, Nijmegen, the Netherlands.
  • Richard Kirsch
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Scarlett Brockmoeller
    Pathology and Data Analytics, Leeds Institute of Medical Research at St. James's School of Medicine, Leeds, UK.
  • Gieri Cathomas
    Institute of Tissue Medicine and Pathology, University of Bern, Murtenstr. 31, 3008, Bern, Switzerland.
  • Rolf Buslei
    Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany.
  • David Fink
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
  • Marie Roumet
    Clinical Trials Unit, University of Bern, Bern, Switzerland.
  • Inti Zlobec
    Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland. inti.zlobec@pathology.unibe.ch.
  • Jeroen van der Laak
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Iris D Nagtegaal
    Department of Pathology, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands.
  • Alessandro Lugli
    Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.