Exploring White Matter Abnormalities in Young Children with Autism Spectrum Disorder: Integrating Multi-shell Diffusion Data and Machine Learning Analysis.

Journal: Academic radiology
PMID:

Abstract

RATIONALE AND OBJECTIVES: This study employed tract-based spatial statistics (TBSS) to investigate abnormalities in the white matter microstructure among children with autism spectrum disorder (ASD). Additionally, an eXtreme Gradient Boosting (XGBoost) model was developed to effectively classify individuals with ASD and typical developing children (TDC).

Authors

  • Yanyong Shen
    Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.); Henan International Joint Laboratory of Neuroimaging, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.).
  • Xin Zhao
    Florida International University.
  • Kaiyu Wang
    MR Research China, GE Healthcare, Beijing, 100000, PR China (K.W.).
  • Yongbing Sun
    Department of Radiology, Henan Provincial People's Hospital, Zhengzhou, 450000, China (Y.S.).
  • Xiaoxue Zhang
    School of Management, Harbin University of Commerce, Harbin, China.
  • Changhao Wang
    Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.); Henan International Joint Laboratory of Neuroimaging, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.).
  • Zhexuan Yang
    Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.); Henan International Joint Laboratory of Neuroimaging, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.).
  • Zhanqi Feng
    Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.); Henan International Joint Laboratory of Neuroimaging, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.).
  • Xiaoan Zhang
    Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.); Henan International Joint Laboratory of Neuroimaging, Zhengzhou, 450052, China (Y.S., X.Z., X.Z., C.W., Z.Y., Z.F., X.Z.). Electronic address: zxa@zzu.edu.cn.