Deep learning segmentation of peri-sinus structures from structural magnetic resonance imaging: validation and normative ranges across the adult lifespan.

Journal: Fluids and barriers of the CNS
Published Date: Feb 13, 2024

Abstract

BACKGROUND: Peri-sinus structures such as arachnoid granulations (AG) and the parasagittal dural (PSD) space have gained much recent attention as sites of cerebral spinal fluid (CSF) egress and neuroimmune surveillance. Neurofluid circulation dysfunction may manifest as morphological changes in these structures, however, automated quantification of these structures is not possible and rather characterization often requires exogenous contrast agents and manual delineation.

Authors

  • Kilian Hett
    Department of Neurology, Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, 1500 21 stAve South, Village at Vanderbilt, Suite 2600, Nashville, TN, 37212, USA.
  • Colin D McKnight
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Melanie Leguizamon
    Dept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Jennifer S Lindsey
    Dept. of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Jarrod J Eisma
    Department of Neurology, Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, 1500 21 stAve South, Village at Vanderbilt, Suite 2600, Nashville, TN, 37212, USA.
  • Jason Elenberger
    Department of Neurology, Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, 1500 21 stAve South, Village at Vanderbilt, Suite 2600, Nashville, TN, 37212, USA.
  • Adam J Stark
    Dept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Alexander K Song
    Department of Neurology, Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, 1500 21 stAve South, Village at Vanderbilt, Suite 2600, Nashville, TN, 37212, USA.
  • Megan Aumann
    Dept. of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ciaran M Considine
    Dept. of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Daniel O Claassen
    Department of Neurology, Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, 1500 21 stAve South, Village at Vanderbilt, Suite 2600, Nashville, TN, 37212, USA.
  • Manus J Donahue
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

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