AIMC Topic: Longevity
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Using Machine Learning to Predict Cognitive Decline in Older Adults From the Chinese Longitudinal Healthy Longevity Survey: Model Development and Validation Study.
JMIR aging
Apr 30, 2025
BACKGROUND: Cognitive impairment, indicative of Alzheimer disease and other forms of dementia, significantly deteriorates the quality of life of older adult populations and imposes considerable burdens on families and health care systems worldwide. T...
An artificial intelligence-informed proof of concept model for an ecological framework of healthy longevity forcing factors in the United States.
Current problems in cardiology
Mar 14, 2025
Unhealthy lifestyle behaviors are a doorway to downstream health consequences characterized by the following: 1) poor quality of life and diminished mobility; 2) increased likelihood of chronic disease risk factors and diagnoses; and, ultimately, 3) ...
Deep learning and generative artificial intelligence in aging research and healthy longevity medicine.
Aging
Jan 16, 2025
With the global population aging at an unprecedented rate, there is a need to extend healthy productive life span. This review examines how Deep Learning (DL) and Generative Artificial Intelligence (GenAI) are used in biomarker discovery, deep aging ...
Metabolomic age (MileAge) predicts health and life span: A comparison of multiple machine learning algorithms.
Science advances
Dec 18, 2024
Biological aging clocks produce age estimates that can track with age-related health outcomes. This study aimed to benchmark machine learning algorithms, including regularized regression, kernel-based methods, and ensembles, for developing metabolomi...
Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice.
Ageing research reviews
Dec 4, 2024
The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluations should...
Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend.
Nature aging
Dec 3, 2024
Aging involves metabolic changes that lead to reduced cellular fitness, yet the role of many metabolites in aging is unclear. Understanding the mechanisms of known geroprotective molecules reveals insights into metabolic networks regulating aging and...
Digital Doppelgängers and Lifespan Extension: What Matters?
The American journal of bioethics : AJOB
Nov 14, 2024
There is an ongoing debate about the ethics of research on lifespan extension: roughly, using medical technologies to extend biological human lives beyond the current "natural" limit of about 120 years. At the same time, there is an exploding interes...
Development of a machine learning-based risk assessment model for loneliness among elderly Chinese: a cross-sectional study based on Chinese longitudinal healthy longevity survey.
BMC geriatrics
Nov 14, 2024
BACKGROUND: Loneliness is prevalent among the elderly and has intensified due to global aging trends. It adversely affects both mental and physical health. Traditional scales for measuring loneliness may yield biased results due to varying definition...
Automatic deep learning segmentation of the hippocampus on high-resolution diffusion magnetic resonance imaging and its application to the healthy lifespan.
NMR in biomedicine
Aug 13, 2024
Diffusion tensor imaging (DTI) can provide unique contrast and insight into microstructural changes with age or disease of the hippocampus, although it is difficult to measure the hippocampus because of its comparatively small size, location, and sha...
Machine Learning and Deep Learning Approaches in Lifespan Brain Age Prediction: A Comprehensive Review.
Tomography (Ann Arbor, Mich.)
Aug 12, 2024
The concept of 'brain age', derived from neuroimaging data, serves as a crucial biomarker reflecting cognitive vitality and neurodegenerative trajectories. In the past decade, machine learning (ML) and deep learning (DL) integration has transformed t...
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