Integrative analysis with machine learning identifies diagnostic and prognostic signatures in neuroblastoma based on differentially DNA methylated enhancers between INSS stage 4 and 4S neuroblastoma.

Journal: Journal of cancer research and clinical oncology
PMID:

Abstract

INTRODUCTION: Accumulating evidence demonstrates that aberrant methylation of enhancers is crucial in gene expression profiles across several cancers. However, the latent effect of differently expressed enhancers between INSS stage 4S and 4 neuroblastoma (NB) remains elusive.

Authors

  • Shan Li
    College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Artificial Intelligence and Biomedical Big Data Research Center, Qingdao University of Science and Technology, Qingdao 266061, China. Electronic address: lishan5600@163.com.
  • Tao Mi
    Department of Urology, Children's Hospital of Chongqing Medical University, Zhongshan 2nd Road, No. 136, Yuzhong District, Chongqing, 400014, China.
  • Liming Jin
    Department of Urology, Children's Hospital of Chongqing Medical University, Zhongshan 2nd Road, No. 136, Yuzhong District, Chongqing, 400014, China.
  • Yimeng Liu
    Department of Pediatric Surgery, Guizhou Provincial People's Hospital, 83 Zhongshan East Road, Nanming, Guiyang, Guizhou 550002, China.
  • Zhaoxia Zhang
    Department of Laboratory Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumuqi, 830000, China.
  • Jinkui Wang
    Department of Urology, Children's Hospital of Chongqing Medical University, Zhongshan 2nd Road, No. 136, Yuzhong District, Chongqing, 400014, China.
  • Xin Wu
    Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Center of Technology Innovation for Synthetic Biology, No. 32, Xiqi Road, Tianjin Airport Economic Park, Tianjin 300308, China. Electronic address: wuxin@tib.cas.cn.
  • Chunnian Ren
    Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Zhaoying Wang
    Department of Urology, Children's Hospital of Chongqing Medical University, Zhongshan 2nd Road, No. 136, Yuzhong District, Chongqing, 400014, China.
  • Xiangpan Kong
    Department of Urology, Children's Hospital of Chongqing Medical University, Zhongshan 2nd Road, No. 136, Yuzhong District, Chongqing, 400014, China.
  • Jiayan Liu
    Department of Urology, Children's Hospital of Chongqing Medical University, Zhongshan 2nd Road, No. 136, Yuzhong District, Chongqing, 400014, China.
  • Junyi Luo
    University of Electronic Science and Technology of China, Chengdu, China.
  • Dawei He
    Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China.