Adoptive cell therapy (ACT) has demonstrated curative potential in select cancers, but its translation to solid tumors such as ovarian cancer (OC) has been hindered by multiple factors, including tumor heterogeneity, immune exclusion, and a profoundl...
Characterizing the tumor immune microenvironment from histopathological images offers opportunities for ex vivo immune profiling and prognostic assessment. However, the TCGA-LIHC dataset lacks direct immune cell composition data. Therefore, this stud...
Medical oncology (Northwood, London, England)
Dec 26, 2025
Adeno-associated virus (AAV) has emerged as a pivotal vector for cancer gene therapy due to its low immunogenicity, non-pathogenicity, and sustained transgene expression capacity. However, the heterogeneity and complexity of the tumor microenvironmen...
OBJECTIVE: To explore the biological foundations of MRI-based prognostic imaging signatures (including radiomics and deep learning signatures) in breast cancer, and to assess the methodological quality of existing studies.
Journal of cancer research and clinical oncology
Dec 16, 2025
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a major type of kidney cancer, making up about 80% of cases, with advanced stages showing low survival rates. Current treatments face challenges like toxicity and drug resistance. Studies indicat...
Immune checkpoint inhibitors have partially improved treatment outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but the response rate remains low, with only a few patients benefiting. Mechanistically, HNSCC tumor cells often ...
Spatial transcriptomics has emerged as a transformative technology in biomedical research, offering unprecedented insights into gene and protein expression within their native tissue context. Unlike conventional bulk or single-cell sequencing approac...
Precision oncology enables molecularly guided cancer therapy through multi-omics profiling, AI-driven classification, and biomarker-targeted interventions. Disulfidptosis has emerged as a promising therapeutic target, yet no ovarian cancer classifica...
The high heterogeneity of colorectal cancer (CRC) complicates accurate prognosis prediction. Hypoxia can affect cell death mechanisms, leading to resistance to many antitumor therapies and potentially causing relapse. Programmed cell death (PCD) form...
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC). Although we have made many achievements in the therapy of RCC with the progress of medicine, the clinical management of metastatic RCC remains a dauntin...
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