The 3D Revolution in Cancer Discovery.

Journal: Cancer discovery
Published Date:

Abstract

The transition from 2D to 3D spatial profiling marks a revolutionary era in cancer research, offering unprecedented potential to enhance cancer diagnosis and treatment. This commentary outlines the experimental and computational advancements and challenges in 3D spatial molecular profiling, underscoring the innovation needed in imaging tools, software, artificial intelligence, and machine learning to overcome implementation hurdles and harness the full potential of 3D analysis in the field.

Authors

  • Linghua Wang
    Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Mingyao Li
    Department of Biostatistics, Epidemiology & Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. mingyao@pennmedicine.upenn.edu.
  • Tae Hyun Hwang