Comparative analysis of the spatial distribution of brain metastases across several primary cancers using machine learning and deep learning models.

Journal: Journal of neuro-oncology
Published Date:

Abstract

OBJECTIVE: Brain metastases (BM) are associated with poor prognosis and increased mortality rates, making them a significant clinical challenge. Studying BMs can aid in improving early detection and monitoring. Systematic comparisons of anatomical distributions of BM from different primary cancers, however, remain largely unavailable.

Authors

  • Saeedeh Mahmoodifar
    Department of Physics & Astronomy, University of Southern California, Los Angeles, CA, 90089, USA.
  • Dhiraj J Pangal
    Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. Electronic address: pangal@usc.edu.
  • Josh Neman
    Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
  • Gabriel Zada
    Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.
  • Jeremy Mason
    Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, University Park Campus, Los Angeles, CA, United States of America.
  • Bodour Salhia
    Department of Translational Genomics Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
  • Tehila Kaisman-Elbaz
    Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Neurological Institute, The Cleveland Clinic, Cleveland, OH, 44195, USA.
  • Selcuk Peker
    Department of Neurosurgery, Koc University School of Medicine, Istanbul, Turkey.
  • Yavuz Samanci
    Department of Neurosurgery, Koc University School of Medicine, Istanbul, Turkey.
  • Andréanne Hamel
    Department of Neurosurgery, Université de Sherbrooke, Centre de recherche du CHUS, QC, Canada.
  • David Mathieu
    Department of Neurosurgery, Université de Sherbrooke, Centre de recherche du CHUS, QC, Canada.
  • Manjul Tripathi
    Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Jason Sheehan
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, 22903, USA.
  • Stylianos Pikis
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, 22903, USA.
  • Georgios Mantziaris
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, 22903, USA.
  • Paul K Newton
    Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California, University Park Campus, Los Angeles, CA, United States of America.