High Mobility Group Box 1 Protein Enhances HIV Replication in Newly Infected Primary T Cells.
Journal:
Clinical laboratory
PMID:
28164548
Abstract
BACKGROUND: High-mobility group box 1 (HMGB1), a DNA-binding protein, has recently been shown to have effects on HIV replication, but the effects are dependent on the cell type and the timing of infection. Using human primary T cells, this study aimed to investigate the role of HMGB1 in HIV-1 replication in newly infected cells.