AIMC Topic: HMGB1 Protein
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Integrating machine learning and bioinformatics approaches to identify novel diagnostic gene biomarkers for diabetic mice.
Scientific reports
Jul 2, 2025
Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding ...
Integrating necroptosis into pan-cancer immunotherapy: a new era of personalized treatment.
Frontiers in immunology
Dec 9, 2024
INTRODUCTION: Necroptosis has emerged as a promising biomarker for predicting immunotherapy responses across various cancer types. Its role in modulating immune activation and therapeutic outcomes offers potential for precision oncology.
Influences of microRNA-451 on the expression of HMGB1 in myocardial cells and its mechanism in ischemia-reperfusion injury.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 31, 2023
This work aimed to understand the underlying mechanism of micro-ribonucleic acid (MicroRNA) (miR)-451 in ischemia-reperfusion injury (IRI) and the influences of miR-451 on high mobility group box 1 protein (HMGB1) in myocardial cells, 30 specific pat...
Artificial Intelligence Predicts Severity of COVID-19 Based on Correlation of Exaggerated Monocyte Activation, Excessive Organ Damage and Hyperinflammatory Syndrome: A Prospective Clinical Study.
Frontiers in immunology
Aug 27, 2021
BACKGROUND: Prediction of the severity of COVID-19 at its onset is important for providing adequate and timely management to reduce mortality.
Drive Pressure-Guided Individualized Positive End-Expiratory Pressure in Traumatic Brain Injury Surgery: A Randomized Controlled Trial.
Annali italiani di chirurgia
Jan 1, 2024
AIM: Intraoperative lung-protective ventilation strategies (LPVS) have been shown to improve lung oxygenation and prevent postoperative pulmonary problems in surgical patients. However, the application of positive end-expiratory pressure (PEEP)-based...
EVALUATION OF THE BEHAVIOR OF LEVELS OF HMGB1 AND IL6 AS PREDICTORS OF INFECTION, ACUTE KIDNEY INJURY AND MORTALITY IN CIRRHOTIC PATIENTS WITH VARICEAL BLEEDING.
Arquivos de gastroenterologia
Jan 1, 2018
BACKGROUND: Gastroesophageal varices and associated bleeding are a major cause of morbidity and mortality in cirrhotic patients.
[Role of high mobility group protein B1 in IL-1α-induced endothelial cell senescence].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Dec 28, 2017
To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelial cells (HUVECs) and the function of high mobility group protein 1 (HMGB1).
Methods: HUVECs were randomly divided into a control group, a IL-1α group...
High Mobility Group Box 1 Protein Enhances HIV Replication in Newly Infected Primary T Cells.
Clinical laboratory
Dec 1, 2016
BACKGROUND: High-mobility group box 1 (HMGB1), a DNA-binding protein, has recently been shown to have effects on HIV replication, but the effects are dependent on the cell type and the timing of infection. Using human primary T cells, this study aime...
[Intervention Effect of Modified Dachengqi Decoction on Intestinal Mucosal Barrier of Severe Acute Pancreatitis Model Rats].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Dec 1, 2015
OBJECTIVE: To study the effect of Modified Dachengqi Decoction (MDD) as whole course therapy on mediators of inflammation in severe acute pancreatitis (SAP) model rats, and to compare interventional advantages over intestinal mucosal barrier (IMB) of...
[Reproduction of a model of "two-hit" sepsis model with complication of pneumonia in rat].
Zhonghua wei zhong bing ji jiu yi xue
Oct 1, 2015
OBJECTIVE: To reproduce a clinically relevant "two-hit" model of sepsis complicated by pneumonia and to explore the correlation between "two-hit" and immune state.
Aspartate Aminotransferases
Random Allocation
Spleen
Blood Urea Nitrogen
Receptors, Tumor Necrosis Factor, Type I
Interleukin-1beta
Transforming Growth Factor beta1
Creatinine
Alanine Transaminase
Animals
Male
Sepsis
Rats
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha
Disease Models, Animal
Interleukin-6
Apoptosis
Pneumonia
HMGB1 Protein
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