Optimizing deep learning-based segmentation of densely packed cells using cell surface markers.

Journal: BMC medical informatics and decision making
PMID: 38750526

Abstract

BACKGROUND: Spatial molecular profiling depends on accurate cell segmentation. Identification and quantitation of individual cells in dense tissues, e.g. highly inflamed tissue caused by viral infection or immune reaction, remains a challenge.

Authors

  • Sunwoo Han
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, USA.
  • Khamsone Phasouk
    Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States.
  • Jia Zhu
    School of Computer Science, South China Normal University, Guangzhou, China. Electronic address: jzhu@m.scnu.edu.cn.
  • Youyi Fong
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, USA. youyifong@gmail.com.

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