Estimation of linezolid exposure in patients with hepatic impairment using machine learning based on a population pharmacokinetic model.

Journal: European journal of clinical pharmacology
Published Date: May 8, 2024

Abstract

PURPOSE: To investigate the pharmacokinetic changes of linezolid in patients with hepatic impairment and to explore a method to predict linezolid exposure.

Authors

  • Ru Liao
    Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
  • Lihong Chen
    NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China.
  • Xiaoliang Cheng
    Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
  • Houli Li
    Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
  • Taotao Wang
    Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
  • Yalin Dong
    Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. dongyalin@mail.xjtu.edu.cn.
  • Haiyan Dong
    Department of Nephrology, Longgang Renmin Hospital, Wenzhou, Zhejiang, P.R. China.

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