BiSpec Pairwise AI: guiding the selection of bispecific antibody target combinations with pairwise learning and GPT augmentation.

Journal: Journal of cancer research and clinical oncology
PMID: 38713378

Abstract

PURPOSE: Bispecific antibodies (BsAbs), capable of targeting two antigens simultaneously, represent a significant advancement by employing dual mechanisms of action for tumor suppression. However, how to pair targets to develop effective and safe bispecific drugs is a major challenge for pharmaceutical companies.

Authors

  • Xin Zhang
    First Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Huiyu Wang
    School of Control Science and Technology, Shandong University, Jinan 250061, PR China. Electronic address: huiyuwang001@163.com.
  • Chunyun Sun
    Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, 100176, China. chunyun_sun@sinocelltech.com.

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