AIMC Topic: Antibodies, Bispecific

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Real-world faricimab switch in France: artificial intelligence-based detection of changes in exudative signs in difficult-to-treat neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 23, 2025
PURPOSE: Some patients with neovascular age-related macular degeneration (nAMD) have persistent signs of exudation under treatment with intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. We examined the real-world anato...
Humans Artificial Intelligence Retrospective Studies France Exudates and Transudates Vascular Endothelial Growth Factor A Drug Substitution Wet Macular Degeneration Antibodies, Bispecific Subretinal Fluid Intravitreal Injections Fluorescein Angiography Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Tomography, Optical Coherence Female Aged, 80 and over Aged Male
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From Molecular Precision to Clinical Practice: A Comprehensive Review of Bispecific and Trispecific Antibodies in Hematologic Malignancies.

International journal of molecular sciences Jun 1, 2025
Multispecific antibodies have redefined the immunotherapeutic landscape in hematologic malignancies. Bispecific antibodies (BsAbs), which redirect cytotoxic T cells toward malignant targets via dual antigen engagement, are now established components ...
Hematologic Neoplasms Immunotherapy Humans Precision Medicine Antineoplastic Agents, Immunological Antibodies, Bispecific
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Retinal fluid quantification using a novel deep learning algorithm in patients treated with faricimab in the TRUCKEE study.

Eye (London, England) Dec 11, 2024
BACKGROUND: Investigate retinal fluid changes via a novel deep-learning algorithm in real-world patients receiving faricimab for the treatment of neovascular age-related macular degeneration (nAMD).
Intravitreal Injections Wet Macular Degeneration Antibodies, Bispecific Subretinal Fluid Aged Aged, 80 and over Tomography, Optical Coherence Retrospective Studies Middle Aged Humans Vascular Endothelial Growth Factor A Female Deep Learning Male Angiogenesis Inhibitors Algorithms Visual Acuity
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BiSpec Pairwise AI: guiding the selection of bispecific antibody target combinations with pairwise learning and GPT augmentation.

Journal of cancer research and clinical oncology May 7, 2024
PURPOSE: Bispecific antibodies (BsAbs), capable of targeting two antigens simultaneously, represent a significant advancement by employing dual mechanisms of action for tumor suppression. However, how to pair targets to develop effective and safe bis...
Humans Machine Learning Neoplasms Antibodies, Bispecific
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Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions.

mAbs Apr 26, 2024
The development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic. These buildin...
Machine Learning Antibodies, Bispecific Humans Immunoglobulin Heavy Chains Single-Domain Antibodies Animals Protein Engineering
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Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab.

Journal of pharmaceutical sciences Dec 22, 2021
We present a novel approach for first-in-human (FIH) dose selection of the CD20xCD3 bispecific antibody, glofitamab, based on pharmacokinetic/pharmacodynamic (PKPD) assessment in cynomolgus monkeys to select a high, safe starting dose, with cytokine ...
Mice Interleukin-6 Antibodies, Bispecific Lymphoma, B-Cell Animals Humans Macaca fascicularis Cytokines
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Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning.

Analytical chemistry Dec 14, 2018
Bispecific antibodies are regarded as the next generation of therapeutic modalities as they can simultaneously bind multiple targets, increasing the efficacy of treatments for several diseases and opening up previously unattainable treatment designs....
Disulfides Cysteine Machine Learning Immunoglobulin G Antibodies, Bispecific
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