Predicting response to neoadjuvant chemotherapy for colorectal liver metastasis using deep learning on prechemotherapy cross-sectional imaging.

Journal: Journal of surgical oncology
PMID: 38712939

Abstract

BACKGROUND AND OBJECTIVES: Deep learning models (DLMs) are applied across domains of health sciences to generate meaningful predictions. DLMs make use of neural networks to generate predictions from discrete data inputs. This study employs DLM on prechemotherapy cross-sectional imaging to predict patients' response to neoadjuvant chemotherapy.

Authors

  • Joshua M K Davis
    Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, USA.
  • Muhammad Khalid Khan Niazi
    Center for Biomedical Informatics, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
  • Ansley B Ricker
    Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, USA.
  • Thomas E Tavolara
    Center for Biomedical Informatics, Wake Forest School of Medicine, Winston-Salem, USA.
  • Jordan N Robinson
    Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, USA.
  • Bayram Annanurov
    Center for Artificial Intelligence Research and the Clinical Image Analysis Lab, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Kaylee Smith
    Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, USA.
  • Rohit Mantha
    Division of HPB Surgery, Department of Surgery, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.
  • Jimmy Hwang
    Department of Medical Oncology, Atrium Health Carolinas Medical Center, Levine Cancer Institute, Charlotte, North Carolina, USA.
  • Ruchi Shrestha
    Department of Radiology, Atrium Health, Charlotte, North Carolina, USA.
  • David A Iannitti
    Division of HPB Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.
  • John B Martinie
    Division of HPB Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.
  • Erin H Baker
    Division of HPB Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.
  • Metin N Gurcan
    Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA. Electronic address: metin.gurcan@osumc.edu.
  • Dionisios Vrochides
    Division of HPB Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.

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