Machine learning evaluation of immune infiltrate through digital tumour score allows prediction of survival outcome in a pooled analysis of three international stage III colon cancer cohorts.

Journal: EBioMedicine
Published Date: Jun 15, 2024

Abstract

BACKGROUND: T-cell immune infiltrates are robust prognostic variables in localised colon cancer. Evaluation of prognosis using artificial intelligence is an emerging field. We evaluated whether machine learning analysis improved prediction of patient outcome in comparison with analysis of T cell infiltrate only or in association with clinical variables.

Authors

  • Julie Lecuelle
    Centre de Recherche INSERM LNC-UMR1231, F-21000 Dijon, France; University of Burgundy Franche-Comté, F-21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, F-21000 Dijon, France.
  • Caroline Truntzer
    Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
  • Debora Basile
    Department of Medical Oncology, San Giovanni di Dio Hospital, Crotone, Italy.
  • Luigi Laghi
    Department of Medicine and Surgery, University of Parma, Parma, Italy; Molecular Gastroenterology Laboratory, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
  • Luana Greco
    Molecular Gastroenterology Laboratory, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
  • Alis Ilie
    Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
  • David Rageot
    Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
  • Jean-François Emile
    EA4340, Ambroise Pare Hospital, Beuvry, Hauts-de-France, France.
  • Frederic Bibeau
    Department of Pathology, Caen University Hospital, Normandy University, Caen, France.
  • Julien Taieb
    Service d'hépato-gastroentérologie, Hopital Europeen Georges Pompidou, Paris, France.
  • Valentin Derangere
    Plateforme de recherche biologique en oncologie, Georges-Francois Leclerc Centre, Dijon, Bourgogne-Franche-Comté, France.
  • Come Lepage
    Département d'hépato-gastroentérologie et en oncologie digestive, Hôpital du Bocage, Dijon, Bourgogne-Franche-Comté, France.
  • François Ghiringhelli
    Département d'oncologie médicale, Georges-Francois Leclerc Centre, Dijon, Bourgogne-Franche-Comté, France fghiringhelli@cgfl.fr.

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