Vancomycin trough concentration in adult patients with periprosthetic joint infection: A machine learning-based covariate model.

Journal: British journal of clinical pharmacology
PMID: 38845212

Abstract

AIMS: Although there are various model-based approaches to individualized vancomycin (VCM) administration, few have been reported for adult patients with periprosthetic joint infection (PJI). This work attempted to develop a machine learning (ML)-based model for predicting VCM trough concentration in adult PJI patients.

Authors

  • Yue-Wen Chen
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Xi-Kai Lin
    School of Mechanical Engineering and Automation, Fuzhou University, FuZhou, China.
  • Chen Huang
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Wei Wu
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Wei-Wei Lin
    Department of Ultrasound, The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
  • Si Chen
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Zong-Xing Lu
    School of Mechanical Engineering and Automation, Fuzhou University, FuZhou, China.
  • Ya-Yi You
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Zhou-Jie Liu
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

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