A transparent machine learning algorithm uncovers HbA1c patterns associated with therapeutic inertia in patients with type 2 diabetes and failure of metformin monotherapy.

Journal: International journal of medical informatics
PMID:

Abstract

AIMS: This study aimed to identify and categorize the determinants influencing the intensification of therapy in Type 2 Diabetes (T2D) patients with suboptimal blood glucose control despite metformin monotherapy.

Authors

  • Nicoletta Musacchio
    Italian Association of Diabetologists, Rome, Italy.
  • Rita Zilich
    Knowledge Management - Mix-x, Milano, Italy.
  • Davide Masi
    Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
  • Fabio Baccetti
    ASL Nordovest Toscana. ASL Nordovest, Massa Carrara (MS), Italy. Electronic address: fabio.baccetti@uslnordovest.toscana.it.
  • Besmir Nreu
    Diabetology Unit, Careggi Hospital, Largo G.A. Brambilla, 3, 50134 Florence (FI), Italy. Electronic address: nreub@aou-careggi.toscana.it.
  • Carlo Bruno Giorda
    Diabetes and Endocrinology Unit, ASL TO5, Chieri, Turin (TO), Italy.
  • Giacomo Guaita
    Diabetology, Endocrinology and Metabolic Diseases Service, Azienda Tutela Salute Sardegna-Azienda Socio Sanitaria Locale, Carbonia, Italy.
  • Lelio Morviducci
    UOC Diabetologia e Dietologia, Ospedale S. Spirito - ASL Roma 1, Borgo Santo Spirito, Roma (RM), Italy. Electronic address: leliomorviducci@aslroma1.it.
  • Marco Muselli
  • Alessandro Ozzello
    Departmental Structure of Endocrine Diseases and Diabetology, Azienda Sanitaria Locale TO3, Pinerolo, Italy.
  • Federico Pisani
    Mix-x Partner, Via Circonvallazione 5, Ivrea (TO), Italy.
  • Paola Ponzani
    Operative Unit of Diabetology, La Colletta Hospital, Azienda Sanitaria Locale 3, Genova, Italy.
  • Antonio Rossi
    IRCCS Ospedale Galeazzi-Sant'Ambrogio, 20149 Milan, Italy; Department of Biomedical and Clinical Sciences, Università di Milano, Milan, Italy. Electronic address: antonio.rossi1@unimi.it.
  • Pierluigi Santin
    Deimos Engineering, 33100 Udine, Italy.
  • Damiano Verda
    Rulex Inc, USA.
  • Graziano Di Cianni
    AMD Past President, Diabetes and Metabolic Diseases Unit, Health Local Unit Nord-West Tuscany, Livorno Hospital, Pad. 4 Viale Alfieri 36, Livorno (LI), Italy. Electronic address: graziano.dicianni@uslnordovest.toscana.it.
  • Riccardo Candido
    Diabetes Center, University Hospital and Health Services of Trieste, Trieste, Italy.