Current opinion in structural biology
Apr 15, 2022
Machine learning methods, in particular convolutional neural networks, have been applied to a variety of problems in cryo-EM and macromolecular crystallographic structure solution. However, they still have only limited acceptance by the community, ma...
Current opinion in structural biology
Feb 23, 2022
Protein-protein interactions (PPIs) are essential in the regulation of biological functions and cell events, therefore understanding PPIs have become a key issue to understanding the molecular mechanism and investigating the design of drugs. Here we ...
Current opinion in structural biology
Feb 10, 2022
Host-microbiome interactions play significant roles in human health and disease. Artificial intelligence approaches have been developed to better understand and predict the molecular interplay between the host and its microbiome. Here, we review rece...
Current opinion in structural biology
Feb 6, 2022
Bolstered by recent methodological and hardware advances, deep learning has increasingly been applied to biological problems and structural proteomics. Such approaches have achieved remarkable improvements over traditional machine learning methods in...
Current opinion in structural biology
Jan 31, 2022
The success of Artificial Intelligence (AI) across a wide range of domains has fuelled significant interest in its application to designing novel compounds and screening compounds against a specific target. However, many existing AI methods either do...
Current opinion in structural biology
Jan 21, 2022
Developing new drugs remains prohibitively expensive, time-consuming, and often involves safety issues. Accurate prediction of drug-target interactions (DTIs) can guide the drug discovery process and thus facilitate drug development. Non-Euclidian da...
Current opinion in structural biology
Dec 25, 2021
Deep learning approaches have produced substantial breakthroughs in fields such as image classification and natural language processing and are making rapid inroads in the area of protein design. Many generative models of proteins have been developed...
Current opinion in structural biology
Dec 23, 2021
Proteins interact through their interfaces to fulfill essential functions in the cell. They bind to their partners in a highly specific manner and form complexes that have a profound effect on understanding the biological pathways they are involved i...
Current opinion in structural biology
Dec 15, 2021
Stability is a key ingredient of protein fitness, and its modification through targeted mutations has applications in various fields, such as protein engineering, drug design, and deleterious variant interpretation. Many studies have been devoted ove...
Current opinion in structural biology
Dec 9, 2021
Machine-learning models that learn from data to predict how protein sequence encodes function are emerging as a useful protein engineering tool. However, when using these models to suggest new protein designs, one must deal with the vast combinatoria...