Microbiomes, complex communities of microorganisms and their genetic material, hold immense potential for addressing global challenges in diverse sectors, including healthcare, agriculture, and bioproduction. Engineering these intricate ecosystems, h...
Host-microbe interactions are increasingly recognized as an important module to understand disease progression and potential treatment strategies. Increasing evidence points to the microbiome's ability to modulate host gene expression, and thereby in...
Liquid biopsies are transforming oncology, enabling earlier diagnosis, dynamic treatment guidance, and personalized precision medicine, yet current approaches focusing mainly on circulating host cell-free DNA (cfDNA) neglect crucial information withi...
Staphylococcus aureus colonises the nose in humans, with individuals defined as persistent, intermittent or non-carriers. Unlike the gut microbiome, the nasal microbiome has not been studied in large numbers of people. Here, we define the nasal micro...
The human microbiome is crucial for health regulation and disease progression, presenting a valuable opportunity for health state classification. Traditional microbiome-based classification relies on pre-trained machine learning (ML) or deep learning...
BACKGROUND: The increasing numbers of sexual violence and unresolved rape cases require alternative approaches with higher evidential value to complement existing forensic tools. Predicting recent intercourse is crucial in forensic casework on sexual...
Longitudinal microbiome data provide a unique opportunity to explore dynamic interactions between microbial communities and disease progression. However, these data are often characterized by missing values, sparse signals, and limited interpretabili...
Persistent organic pollutants (POPs) are harmful chemicals that resist degradation and remain in the environment for a long time. These pollutants originate from various sources, such as industrial, agricultural, and waste disposal. They contaminate ...
BACKGROUND: Checkpoint inhibitor pneumonitis (CIP) is among the most lethal immune-related adverse events in patients with cancer receiving immunotherapy. This study aims to characterize the lung microbiome in patients with CIP and evaluate its diagn...
Understanding species-level abundance dynamics in complex microbial communities is key to managing microbial ecosystems, yet it remains a major challenge. In wastewater treatment plants (WWTPs), the presence and abundance of process-critical bacteria...
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