Frontiers in microbiology
Jan 28, 2020
BACKGROUND: The increase in carbapenem-resistant (CRKP), especially the emergence of tigecycline-resistant (KP), is a serious public health concern. However, the underlying mechanism of tigecycline resistance is unclear. In this study, we evaluated...
Frontiers in microbiology
Jan 22, 2020
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally occurring and synthetic AMPs have shown promising results against a series of c...
Frontiers in microbiology
Jan 21, 2020
The rise of antifungal drug resistance in species responsible for life threatening candidiasis is considered as an increasing challenge for the public health. MCh-AMP1 has previously been reported as a natural peptide from L. flowers with broad-spe...
Frontiers in microbiology
Jan 15, 2020
The emergence of drug-resistant (Mtb) has hampered treatments for tuberculosis, which consequently now require novel agents to overcome such drug resistance. The genetically stable D-alanine-D-alanine ligase A (DdlA) has been deemed as an excellent ...
Frontiers in microbiology
Jan 15, 2020
Otitis media (OM) is a prevalent pediatric infection characterized by painful inflammation of the middle ear. The Gram-negative diplococcus is a commensal of the nasopharynx and one of three leading causative agents of OM. The most recent work on th...
Frontiers in microbiology
Jan 14, 2020
causes life-threatening systemic infections in immunosuppressed patients. These infections are commonly treated with fluconazole, an antifungal agent targeting the ergosterol biosynthesis pathway. Current Antifungal Susceptibility Testing (AFST) met...
Frontiers in microbiology
Nov 26, 2019
species often cause disease in farmed fish. In the present study, dominant bacteria were isolated from diseased crucian carp (). Based on this, a bacterial isolate was tentatively named CFJY-623. This isolate was identified as based on analysis of ...
Frontiers in microbiology
Jan 31, 2019
The incidence of resistant isolates has increased continuously in recent decades, especially . To overcome this resistance, research on antifungal sensitizers has attracted considerable attention. Linezolid was found to inhibit the growth of and sy...
Frontiers in microbiology
Jan 14, 2019
We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from UppS is an essential enzyme in the biosynthesis of bacterial cell wall. It catalyzes the condensation ...
Frontiers in microbiology
Jan 9, 2019
Quorum sensing (QS), one of the most remarkable microbiological discoveries, is considered a global gene regulatory mechanism for various traits in bacteria, including virulence and spoilage. , an opportunistic pathogen and a dominant psychrophile, u...