Predictive models (a.k.a. machine learning models) are ubiquitous in all stages of drug research, safety, development, manufacturing, and marketing. The results of these models are used inside and outside of pharmaceutical companies for the purpose o...
Post marketing data offer rich information and cost-effective resources for physicians and policy-makers to address some critical scientific questions in clinical practice. However, the complex confounding structures (e.g., nonlinear and nonadditive ...
It is well-known that a spontaneous reporting system suffers from significant under-reporting of adverse drug reactions from the source population. The existing methods do not adjust for such under-reporting for the calculation of measures of associa...