Xenobiotica; the fate of foreign compounds in biological systems
May 12, 2025
1. The research aims to develop and validate a stability-indicating reverse phase high-performance liquid chromatography (RP-HPLC) method for Lurasidone hydrochloride, an antipsychotic drug derived from benzisothiazole derivatives. 2. A Binary Gradie...
Xenobiotica; the fate of foreign compounds in biological systems
Aug 21, 2024
A drug's pharmacokinetic (PK) profile will determine its dose and the frequency of administration as well as the likelihood of observing any adverse drug reactions.It is important to understand these PK properties as early as possible in the drug dis...
Xenobiotica; the fate of foreign compounds in biological systems
Aug 21, 2024
Artificial Intelligence (AI) is poised or has already begun to influence absorption, distribution, metabolism and excretion (ADME) science. It is not in the area expected - that of superior modelling of ADME data to increase its predictive power. It ...
Xenobiotica; the fate of foreign compounds in biological systems
Aug 21, 2024
Unexpected metabolism could lead to the failure of many late-stage drug candidates or even the withdrawal of approved drugs. Thus, it is critical to predict and study the dominant routes of metabolism in the early stages of research.We describe the d...