AIMC Topic: Amino Acid Substitution

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Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2.

Proceedings of the National Academy of Sciences of the United States of America Oct 19, 2021
The association of the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with human angiotensin-converting enzyme 2 (hACE2) represents the first required step for cellular entry. SARS-CoV-2 ha...
Humans Neural Networks, Computer SARS-CoV-2 Spike Glycoprotein, Coronavirus Molecular Dynamics Simulation Host-Pathogen Interactions Angiotensin-Converting Enzyme 2 Amino Acid Substitution Binding Sites
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A systematic exploration of [Formula: see text] cutoff ranges in machine learning models for protein mutation stability prediction.

Journal of bioinformatics and computational biology Oct 1, 2018
Discerning how a mutation affects the stability of a protein is central to the study of a wide range of diseases. Mutagenesis experiments on physical proteins provide precise insights about the effects of amino acid substitutions, but such studies ar...
Neural Networks, Computer Machine Learning Algorithms Computational Biology Support Vector Machine Proteins Mutation Protein Stability Random Allocation Amino Acid Substitution
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