AIMC Topic: Amino Acyl-tRNA Synthetases

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Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids.

Nature communications Jul 19, 2025
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, the yields of most ncAA-containing protein  remain low due to the limited activity of PylRS variants. Here, we apply machine...
Machine Learning Mutation Amino Acids RNA, Transfer Lysine Directed Molecular Evolution Protein Engineering Codon, Terminator Amino Acyl-tRNA Synthetases
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Uncovering substrate specificity determinants of class IIb aminoacyl-tRNA synthetases with machine learning.

Journal of molecular graphics & modelling Jul 14, 2024
Specific amino acid (AA) binding by aminoacyl-tRNA synthetases (aaRSs) is necessary for correct translation of the genetic code. Sequence and structure analyses have revealed the main specificity determinants and allowed a partitioning of aaRSs into ...
Machine Learning Models, Molecular Amino Acid Sequence Substrate Specificity Amino Acyl-tRNA Synthetases
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