AIMC Topic: Codon, Terminator

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Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids.

Nature communications Jul 19, 2025
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, the yields of most ncAA-containing protein  remain low due to the limited activity of PylRS variants. Here, we apply machine...
Machine Learning Mutation Amino Acids RNA, Transfer Lysine Directed Molecular Evolution Protein Engineering Codon, Terminator Amino Acyl-tRNA Synthetases
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Deep learning modeling mA deposition reveals the importance of downstream cis-element sequences.

Nature communications May 17, 2022
The N-methyladenosine (mA) modification is deposited to nascent transcripts on chromatin, but its site-specificity mechanism is mostly unknown. Here we model the mA deposition to pre-mRNA by iM6A (intelligent mA), a deep learning method, demonstratin...
Deep Learning Methylation Base Sequence Regulatory Sequences, Nucleic Acid Codon, Terminator
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Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy Using Machine Learning.

Molecules (Basel, Switzerland) Aug 26, 2020
A significant percentage of Duchenne muscular dystrophy (DMD) cases are caused by premature termination codon (PTC) mutations in the dystrophin gene, leading to the production of a truncated, non-functional dystrophin polypeptide. PTC-suppressing com...
Humans Machine Learning Databases, Chemical Muscular Dystrophy, Duchenne Codon, Terminator Dystrophin
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Predicting functional consequences of SNPs on mRNA translation via machine learning.

Nucleic acids research Aug 25, 2023
The functional impact of single nucleotide polymorphisms (SNPs) on translation has yet to be considered when prioritizing disease-causing SNPs from genome-wide association studies (GWAS). Here we apply machine learning models to genome-wide ribosome ...
Machine Learning Genome-Wide Association Study Polymorphism, Single Nucleotide RNA, Messenger Protein Biosynthesis Codon, Terminator
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