Lysine 2-hydroxyisobutyrylation (Khib) has emerged as a crucial Post-Translational Modification (PTM) with significant roles in diverse biological processes ranging from gene expression to metabolic regulation. Despite its importance, computational a...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Nov 3, 2025
Metastatic castration-resistant prostate cancer has a high rate of mortality with a limited number of effective treatments after hormone therapy. Radiopharmaceutical therapy with [Lu]Lu-prostate-specific membrane antigen-617 (LuPSMA) is one treatment...
Skin sensitization is a critical endpoint in toxicology, especially in the context of drug discovery and development process for topical and transdermal treatments. Accurate evaluation of skin sensitization potential is essential to ensure the safety...
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, the yields of most ncAA-containing protein remain low due to the limited activity of PylRS variants. Here, we apply machine...
Ubiquitination is critical in biomedical research. Predicting ubiquitination sites based on deep learning model have advanced the study of ubiquitination. However, traditional supervised model limits in the scenarios where labels are scarcity across ...
The Maillard reaction generates hazardous processing contaminants, including acrylamide (AA) and Nε-(carboxymethyl)lysine (CML), necessitating effective inhibitors. Here we use machine learning approaches to predict how catechin treatment reduces sim...
BACKGROUND: Gastric cancer (GC) is a highly aggressive and heterogeneous cancer with extremely complex biological characteristics. Lysine and its metabolism are closely related to human cancer, but little is known about how lysine metabolism-related ...
Lysine acetylation (Kace) is one of the most important post-translational modifications. It is key to identify Kace sites for understanding regulation mechanisms in Camellia sinensis. In this study, we defined a mathematical formula, named sequence s...
Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified that MprF synthesizes lysyl-phosphatidylgl...
Chembiochem : a European journal of chemical biology
Dec 5, 2024
Highly selective C-H functionalization remains an ongoing challenge in organic synthetic methodologies. Biocatalysts are robust tools for achieving these difficult chemical transformations. Biocatalyst engineering has often required directed evolutio...
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