AIMC Topic: Dihydroergotoxine

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A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy.

Bioorganic & medicinal chemistry Nov 27, 2021
Colorectal cancer (CRC) is the third most detected cancer and the second foremost cause of cancer deaths in the world. Intervention targeting p53 provides potential therapeutic strategies, but thus far no p53-based therapy has been successfully trans...
Humans Machine Learning Colorectal Neoplasms Molecular Docking Simulation Drug Discovery Antineoplastic Agents Cell Line, Tumor Cell Proliferation Dose-Response Relationship, Drug Cell Survival Drug Screening Assays, Antitumor Structure-Activity Relationship Molecular Structure Tumor Suppressor Protein p53 Dihydroergotoxine
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