AIMC Topic: Neurons

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Deep learning-based cell type profiles reveal signatures of Alzheimer's disease resilience and resistance.

Brain : a journal of neurology
Neurological disorders result from the complex and poorly understood contributions of many cell types. It is therefore essential to uncover mechanisms behind these disorders and identify specific therapeutic targets. Single-nucleus technologies have ...

HL-BscPF: Hybrid learning facilitates brain cell auto-identification in multiple pathologies.

Life sciences
AIMS: The rapidly growing scale and complexity of single-cell transcriptomic data in brain research make it increasingly difficult for traditional methods to extract meaningful insights efficiently, highlighting the need for artificial intelligence.

Effects of vascular endothelial cells on the neurite outgrowth of nerve cells.

Journal of bioscience and bioengineering
The vascular and neuronal networks are structurally complex and highly branched. These networks play an important role in supplying oxygen and sending signals to the tissues and organs in the body. This study proposes procedures to prepare in vitro n...

Visualizing nuclear pore complex plasticity with pan-expansion microscopy.

The Journal of cell biology
The exploration of cell-type and environmentally responsive nuclear pore complex (NPC) plasticity requires new, accessible tools. Using pan-expansion microscopy (pan-ExM), NPCs were identified by machine learning-facilitated segmentation. They exhibi...

Rethinking cell-based neural architecture search: A theoretical perspective.

Neural networks : the official journal of the International Neural Network Society
In this paper, we explore several fundamental theoretical issues in cell-based neural architecture search, including whether different architectures in search space are equally important in terms of the minimal training loss they can achieve, and whe...

Evaluating safe infrared neural stimulation parameters: Calcium dynamics and excitotoxicity thresholds in dorsal root ganglia neurons.

Journal of neuroscience methods
BACKGROUND: As a promising neural stimulation technique, infrared neural stimulation (INS) has recently gained significant attention due to its ability to stimulate neuronal activities without needing exogenous agents. NIR light is absorbed by water ...

Implementing feature binding through dendritic networks of a single neuron.

Neural networks : the official journal of the International Neural Network Society
A single neuron receives an extensive array of synaptic inputs through its dendrites, raising the fundamental question of how these inputs undergo integration and summation, culminating in the initiation of spikes in the soma. Experimental and comput...

Cortical-subcortical neural networks for motor learning and storing sequence memory.

Neural networks : the official journal of the International Neural Network Society
Motor sequence learning relies on the synergistic collaboration of multiple brain regions. However, most existing models for motor sequence learning primarily focus on functional-level analyses of sequence memory mechanisms, providing limited neuroph...

Synergistic Pathways of Modulation Enable Robust Task Packing Within Neural Dynamics.

Neural computation
Understanding how brain networks learn and manage multiple tasks simultaneously is of interest in both neuroscience and artificial intelligence. In this regard, a recent research thread in theoretical neuroscience has focused on how recurrent neural ...

Exploring the Architectural Biases of the Cortical Microcircuit.

Neural computation
The cortex plays a crucial role in various perceptual and cognitive functions, driven by its basic unit, the canonical cortical microcircuit. Yet, we remain short of a framework that definitively explains the structure-function relationships of this ...