AIMC Topic: Receptor, Cannabinoid, CB1

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Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method.

eLife Nov 3, 2025
New psychoactive substances (NPS) targeting human cannabinoid receptor 1 pose a significant threat to society as recreational abusive drugs that have pronounced physiological side effects. These greater adverse effects compared to classical cannabino...
Humans Protein Binding Signal Transduction Kinetics Molecular Dynamics Simulation Psychotropic Drugs Cannabinoids Receptors, Cannabinoid Receptor, Cannabinoid, CB1
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Auxiliary Discrminator Sequence Generative Adversarial Networks for Few Sample Molecule Generation.

Journal of chemical information and modeling Sep 22, 2025
In this work, we introduce auxiliary discriminator sequence generative adversarial networks (ADSeqGAN), a novel approach for molecular generation in small-sample data sets. Traditional generative models often struggle with limited training data, part...
Humans Neural Networks, Computer Drug Discovery Ligands Receptor, Cannabinoid, CB1 Generative Adversarial Networks
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Prediction and Experimental Confirmation of Novel Peripheral Cannabinoid-1 Receptor Antagonists.

Journal of chemical information and modeling Sep 4, 2019
Small molecules targeting peripheral CB1 receptors have therapeutic potential in a variety of disorders including obesity-related, hormonal, and metabolic abnormalities, while avoiding the psychoactive effects in the central nervous system. We applie...
Machine Learning Computer Simulation Computational Biology Ligands Small Molecule Libraries Receptor, Cannabinoid, CB1
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