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Somatic Hypermutation, Immunoglobulin

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Interpretable deep learning reveals the role of an E-box motif in suppressing somatic hypermutation of AGCT motifs within human immunoglobulin variable regions.

Frontiers in immunology 38863710
INTRODUCTION: Somatic hypermutation (SHM) of immunoglobulin variable (V) regions by activation induced deaminase (AID) is essential for robust, long-term humoral immunity against pathogen and vaccine antigens. AID mutates cytosines preferentially wit...
AICDA (Activation-Induced Cytidine Deaminase) Amino Acid Motifs Cytidine Deaminase Deep Learning Humans Immunoglobulin Variable Region Mutation Nucleotide Motifs Somatic Hypermutation, Immunoglobulin
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