The synchronous upregulation of a specific protein cluster in the blood predicts both colorectal cancer risk and patient immune status.

Journal: Gene
PMID:

Abstract

BACKGROUND: Early detection and treatment of colorectal cancer (CRC) is crucial for improving patient survival rates. This study aims to identify signature molecules associated with CRC, which can serve as valuable indicators for clinical hematological screening.

Authors

  • Bingkun Chen
    Division of Gastroenterology, Institute of Digestive Diseases, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan 511518, Guang Dong, China; Department of Histology and Embryology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Guiqing Zhou
    Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China.
  • Anming Chen
    Division of Gastroenterology, Institute of Digestive Diseases, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan 511518, Guang Dong, China.
  • Qian Peng
  • Li Huang
    National Research Center for Resettlement (NRCR), Hohai University, 1 Xikang Road, Nanjing 210098, China. lily8214@hhu.edu.cn.
  • Shanshan Liu
    Department of Orthopaedics, Peking University Third Hospital, Beijing, China.
  • Yue Huang
    Xiamen University, Xiamen, Fujian 361005, China.
  • Xueyun Liu
    Department of Histology and Embryology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Shi Wei
    College of Agriculture, Northeast Agricultural University, Harbin, China.
  • Zhi-Yao Hou
    Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Linhai Li
    School of Biomedical Engineering, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
  • Ling Qi
    Division of Gastroenterology, Institute of Digestive Diseases, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan 511518, Guang Dong, China. Electronic address: qiling1718@gzhmu.edu.cn.
  • Ning-Fang Ma
    Department of Histology and Embryology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: nfma@gzhmu.edu.cn.