Diagnosis of Hirschsprung disease by analyzing acetylcholinesterase staining using artificial intelligence.

Journal: Journal of pediatric gastroenterology and nutrition
PMID: 39118474

Abstract

OBJECTIVES: Classical Hirschsprung disease (HD) is defined by the absence of ganglion cells in the rectosigmoid colon. The diagnosis is made from rectal biopsy, which reveals the aganglionosis and the presence of cholinergic hyperinnervation. However, depending on the method of rectal biopsy, the quality of the specimens and the related diagnostic accuracy varies substantially. To facilitate and objectify the diagnosis of HD, we investigated whether software-based identification of cholinergic hyperinnervation in digitalized histopathology slides is suitable for distinguishing healthy individuals from affected individuals.

Authors

  • Yannick Braun
    Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany.
  • Florian Friedmacher
    Department of Pediatric and Adolescent Surgery, Medical University Graz , Graz, Austria .
  • Till-Martin Theilen
    Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany.
  • Henning C Fiegel
    Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany.
  • Katharina Weber
    Neurological Institute, Edinger Institute, Neuropathology, Goethe University, Frankfurt am Main, Germany.
  • Patrick N Harter
    Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.
  • Udo Rolle
    Department of Pediatric Surgery and Pediatric Urology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany.

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