Clinical Validation of Digitally Acquired Clinical Data and Machine Learning Models for Remote Measurement of Psoriasis and Psoriatic Arthritis: A Proof-of-Concept Study.

Journal: The Journal of rheumatology
PMID:

Abstract

OBJECTIVE: Psoriatic disease remains underdiagnosed and undertreated. We developed and validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous and musculoskeletal signs and symptoms of psoriatic disease.

Authors

  • Dan E Webster
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Rebecca H Haberman
    R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Lourdes M Perez-Chada
    L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Meghasyam Tummalacherla
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Aryton Tediarjo
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Vijay Yadav
    AiCure, New York, New York, USA.
  • Elias Chaibub Neto
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Woody MacDuffie
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Michael DePhillips
    M. DePhillips, BS, E. Sieg, BS, SDP Digital, Seattle, Washington, USA.
  • Eric Sieg
    M. DePhillips, BS, E. Sieg, BS, SDP Digital, Seattle, Washington, USA.
  • Sydney Catron
    R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Carly Grant
    L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Wynona Francis
    L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Marina Nguyen
    L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Muibat Yussuff
    L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Rochelle L Castillo
    R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Di Yan
    Department of Radiation Oncology, Beaumont Health, Royal Oak, Michigan.
  • Andrea L Neimann
    D. Yan, MD, A.L. Neimann, MD, MSCE, Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA.
  • Soumya M Reddy
    R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Alexis Ogdie
    A. Ogdie, MD, MSCE, Department of Medicine, Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Athanassios Kolivras
    A. Kolivras, MD, PhD, Departments of Dermatology and Dermatopathology, Saint-Pierre, Brugmann and Queen Fabiola Children University Hospitals, Université Libre de Bruxelles, Brussels, and UCB Pharma, Brussels, Belgium.
  • Michael R Kellen
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Lara M Mangravite
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Solveig K Sieberts
    D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Larsson Omberg
    Sage Bionetworks, Seattle, WA 98109 USA.
  • Joseph F Merola
    J.F. Merola, MD, MMSc, Department of Dermatology and Department of Medicine, Division of Rheumatology, UT Southwestern Medical Center, Dallas, Texas, USA.
  • Jose U Scher
    R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA; Jose.Scher@nyulangone.org.