Deep Learning Features Can Improve Radiomics-Based Prostate Cancer Aggressiveness Prediction.

Journal: JCO clinical cancer informatics
Published Date:

Abstract

PURPOSE: Emerging evidence suggests that the use of artificial intelligence can assist in the timely detection and optimization of therapeutic approach in patients with prostate cancer. The conventional perspective on radiomics encompassing segmentation and the extraction of radiomic features considers it as an independent and sequential process. However, it is not necessary to adhere to this viewpoint. In this study, we show that besides generating masks from which radiomic features can be extracted, prostate segmentation and reconstruction models provide valuable information in their feature space, which can improve the quality of radiomic signatures models for disease aggressiveness classification.

Authors

  • Nuno M Rodrigues
    LASIGE, Department of Informatics, Faculty of Sciences, University of Lisbon, Lisbon, Portugal.
  • José Guilherme de Almeida
    Champalimaud Foundation, Centre for the Unknown, Lisbon, Portugal.
  • Ana Rodrigues
    Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal.
  • Leonardo Vanneschi
    NOVA IMS, Universidade Nova de Lisboa, 1070-312 Lisboa, Portugal.
  • Celso Matos
    Champalimaud Foundation, Lisbon, Portugal.
  • Maria V Lisitskaya
    Cand. of Sci. (Med.), Radiologist at Radiology Department with CT and MRI, Medical Research and Educational Center, Lomonosov Moscow State University, Moscow, Russia.
  • Aycan Uysal
    Gulhane Medical School, University of Health Sciences, Ankara, Turkey.
  • Sara Silva
    LASIGE, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.
  • Nickolas Papanikolaou
    Champalimaud Foundation, Lisbon, Portugal.